Ingredients
Discover the science behind R4 Core's powerful formulation. This page provides detailed insights into the research supporting each ingredient in our product. Explore how these components work together to enhance health and well-being, with evidence-backed benefits such as boosting immunity, increasing energy levels, reducing stress, and promoting recovery. Each ingredient is supported by clinical studies and scientific findings, ensuring that R4 Core is not only effective but also grounded in reliable research for optimal results.
Hydroxytryptophan (5-HTP) - 100 mg per Serving
Why You'll Love It:
What the Science Says:
5-HTP is the go-to for boosting serotonin in your brain quickly and effectively. Stress, lack of sleep, and exposure to toxins can drain your serotonin levels, leading to feelings of irritability, anxiety, insomnia, and even depression. But 5-HTP helps get those serotonin levels back on track for a healthier mind and better mood!
Source: Birdsall, T.C. (1998). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev, 3(4), 271-280.
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- Boosts Your Happy Hormone: This amino acid helps ramp up serotonin production.
- Keeps Your Mood in Check: Helps prevent serotonin depletion and protects your brain.
- Say Goodbye to the Blues: Supports a positive mood and can ease anxiety.
- Sweet Dreams: Promotes better sleep patterns.
What the Science Says:
5-HTP is the go-to for boosting serotonin in your brain quickly and effectively. Stress, lack of sleep, and exposure to toxins can drain your serotonin levels, leading to feelings of irritability, anxiety, insomnia, and even depression. But 5-HTP helps get those serotonin levels back on track for a healthier mind and better mood!
Source: Birdsall, T.C. (1998). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev, 3(4), 271-280.
Read more here.
Acetyl Carnitine HCl - 250 mg per Serving
Why You'll Love It:
What the Science Says:
Acetyl Carnitine HCl is a powerhouse for your brain, working to protect neurons from oxidative damage and boost brain cell activity. It’s great for lifting your mood and improving memory. Plus, studies show that it helps reduce free radicals and aids in exercise recovery by minimizing tissue damage. When paired with Acetyl, which helps recharge your energy levels, you get the best of both worlds for recovery—something most forms of Carnitine don’t offer.
Source: Glade MJ. (2010). Oxidative stress and cognitive longevity. Nutrition, 26(6), 595-603.
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Source: Huang A, Owen K. (2012). Role of supplementary Acetyl Carnitine in exercise and exercise recovery. Med Sport Sci, 59, 135-142.
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- Brain Buddy: Helps protect and repair your brain cells.
- Cognitive Boost: Enhances cognitive function for sharper thinking.
- Mood Support: Keeps your brain healthy and helps maintain a positive mood.
- Recovery Champion: Aids in recovering after workouts.
What the Science Says:
Acetyl Carnitine HCl is a powerhouse for your brain, working to protect neurons from oxidative damage and boost brain cell activity. It’s great for lifting your mood and improving memory. Plus, studies show that it helps reduce free radicals and aids in exercise recovery by minimizing tissue damage. When paired with Acetyl, which helps recharge your energy levels, you get the best of both worlds for recovery—something most forms of Carnitine don’t offer.
Source: Glade MJ. (2010). Oxidative stress and cognitive longevity. Nutrition, 26(6), 595-603.
Read more here.
Source: Huang A, Owen K. (2012). Role of supplementary Acetyl Carnitine in exercise and exercise recovery. Med Sport Sci, 59, 135-142.
Read more here.
Alpha Lipoic Acid - 50 mg per Serving
Why You'll Love It:
What the Science Says:
Alpha Lipoic Acid is a fatty acid found in every cell of your body, essential for turning glucose into energy for all your normal functions. Unlike other antioxidants that only work in water or fat, Alpha Lipoic Acid is the "universal antioxidant" because it’s both fat and water-soluble, allowing it to work throughout the body. As antioxidants like Vitamin C and E deplete while fighting free radicals, Alpha Lipoic Acid can actually recycle them, bringing them back to life. This means it not only protects your body but also supercharges the healing powers of other antioxidants!
Source: Packer L, Tritschler HJ, Wessel K. (1997). Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radical Biology & Medicine, 22(1–2), 359–378.
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- Universal Antioxidant: Your ultimate defense against free radicals.
- Brain Booster: Increases blood flow and oxygen to the nerves, enhancing brain function and memory.
- Liver Detox: Helps cleanse and detoxify your liver.
- Antioxidant Recycler: Revives key antioxidants like Vitamin C and Vitamin E.
What the Science Says:
Alpha Lipoic Acid is a fatty acid found in every cell of your body, essential for turning glucose into energy for all your normal functions. Unlike other antioxidants that only work in water or fat, Alpha Lipoic Acid is the "universal antioxidant" because it’s both fat and water-soluble, allowing it to work throughout the body. As antioxidants like Vitamin C and E deplete while fighting free radicals, Alpha Lipoic Acid can actually recycle them, bringing them back to life. This means it not only protects your body but also supercharges the healing powers of other antioxidants!
Source: Packer L, Tritschler HJ, Wessel K. (1997). Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radical Biology & Medicine, 22(1–2), 359–378.
Read more here.
Coenzyme Q10 - 30 mg per Serving
Why You’ll Love It:
What the Science Says:
Coenzyme Q10, or CoQ10, is a powerful antioxidant that neutralizes free radicals and helps prevent neurotoxicity. It plays a vital role in protecting your brain and nervous system from damage while combating fatigue. CoQ10 improves energy production in your cells, ensuring your brain stays active and healthy!
Source: Somayajulu M et al. (2005). Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis, 18(3), 618-627.
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- Brain Power: A key antioxidant that supports brain activity.
- Mood Booster: Helps increase serotonin production.
- Neuro Protection: Reduces the risk of neurotoxicity.
- Immune Support: Enhances immune function.
What the Science Says:
Coenzyme Q10, or CoQ10, is a powerful antioxidant that neutralizes free radicals and helps prevent neurotoxicity. It plays a vital role in protecting your brain and nervous system from damage while combating fatigue. CoQ10 improves energy production in your cells, ensuring your brain stays active and healthy!
Source: Somayajulu M et al. (2005). Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis, 18(3), 618-627.
Read more here.
Vitamin E (from d-alpha Tocopheryl Succinate) - 150 IU per Serving
Why You’ll Love It:
What the Science Says:
Vitamin E is a fat-soluble vitamin, which means it sticks around in your body longer than water-soluble vitamins and can dive deep into fatty tissues (including the brain). It’s one of the most effective antioxidants, crucial for protecting cell membranes. It helps keep your immune system strong and is essential for the health of your heart, muscles, and nerves. Plus, Vitamin E prevents brain cell damage, enhances physical endurance, and aids in overall body restoration. d-alpha Tocopheryl Succinate is the natural form of Vitamin E and is twice as bioavailable (easier for your body to use) compared to the synthetic versions found in many supplements.
Source: Brigelius-Flohé; Traber, MG (1999). Vitamin E: function and metabolism. The FASEB Journal, 13(10), 1145-1155.
Read more here.
- Antioxidant Powerhouse: Reduces free radical formation.
- Brain Protector: Shields brain cells from damage.
- Immune Booster: Strengthens your immune system.
- Heart & Muscle Health: Supports a healthy heart, muscles, and nerves.
What the Science Says:
Vitamin E is a fat-soluble vitamin, which means it sticks around in your body longer than water-soluble vitamins and can dive deep into fatty tissues (including the brain). It’s one of the most effective antioxidants, crucial for protecting cell membranes. It helps keep your immune system strong and is essential for the health of your heart, muscles, and nerves. Plus, Vitamin E prevents brain cell damage, enhances physical endurance, and aids in overall body restoration. d-alpha Tocopheryl Succinate is the natural form of Vitamin E and is twice as bioavailable (easier for your body to use) compared to the synthetic versions found in many supplements.
Source: Brigelius-Flohé; Traber, MG (1999). Vitamin E: function and metabolism. The FASEB Journal, 13(10), 1145-1155.
Read more here.
Vitamin B3 (Niacin) - 20 mg per Serving
Why You’ll Love It:
What the Science Says:
Vitamin B3 opens up capillaries and blood vessels, letting oxygen-rich blood work its magic to detoxify your system. Stress can cause blood to retreat to the body’s core, but Vitamin B3 helps restore and enhance blood flow, speeding up toxin removal and boosting overall wellness.
Source: Am J Cardiol. (2008). Mechanism of action of niacin. 101(8A), 20B-26B.
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- Detox Champion: Helps cleanse the body of toxins.
- Quick Recovery: Promotes faster recovery after exertion.
- Circulation Booster: Improves blood flow and fights fatigue.
- Nervous System Support: Keeps your nervous system healthy.
What the Science Says:
Vitamin B3 opens up capillaries and blood vessels, letting oxygen-rich blood work its magic to detoxify your system. Stress can cause blood to retreat to the body’s core, but Vitamin B3 helps restore and enhance blood flow, speeding up toxin removal and boosting overall wellness.
Source: Am J Cardiol. (2008). Mechanism of action of niacin. 101(8A), 20B-26B.
Read more here.
Vitamins B6 (from Pyridoxine HCL) - 25 mg per Serving
Why You’ll Love It:
What the Science Says:
Vitamin B6 plays a vital role in the body, from keeping your immune system healthy to helping form key neurotransmitters like serotonin. Research shows that taking 5-HTP alongside Vitamin B6 makes it much more effective at increasing serotonin in the brain. Many people may not get enough Vitamin B6, as factors like alcohol, caffeine, and physical activity can deplete it. This vitamin is essential for converting 5-HTP into serotonin, boosting your natural energy, and defending against stress.
Source: Hartvig P et al. (1995). Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography. J Neural Trans, 102, 91-97.
Read more here.
Source: Dakshinamurti K et al. (1990). Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats. Klin Wochenschr, 68, 142-145.
Read more here.
Source: Dakshinamurti K et al. (1976). Nonparallel changes in brain monoamines of pyridoxine deficient growing rats. Exp Brain Res, 26, 355-366.
Read more here.
- Serotonin Supercharger: Helps convert 5-HTP into serotonin, boosting its effects.
- Energy Booster: Increases energy levels and sharpens mental focus.
- Immune Support: Strengthens your immune system.
- Better Magnesium Absorption: Enhances the bioavailability of magnesium, making it easier for your body to use.
What the Science Says:
Vitamin B6 plays a vital role in the body, from keeping your immune system healthy to helping form key neurotransmitters like serotonin. Research shows that taking 5-HTP alongside Vitamin B6 makes it much more effective at increasing serotonin in the brain. Many people may not get enough Vitamin B6, as factors like alcohol, caffeine, and physical activity can deplete it. This vitamin is essential for converting 5-HTP into serotonin, boosting your natural energy, and defending against stress.
Source: Hartvig P et al. (1995). Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography. J Neural Trans, 102, 91-97.
Read more here.
Source: Dakshinamurti K et al. (1990). Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats. Klin Wochenschr, 68, 142-145.
Read more here.
Source: Dakshinamurti K et al. (1976). Nonparallel changes in brain monoamines of pyridoxine deficient growing rats. Exp Brain Res, 26, 355-366.
Read more here.
Magnesium (from Magnesium Citrate) - 125 mg per Serving
Why You’ll Love It:
What the Science Says:
Magnesium is crucial for over 300 biochemical reactions in your body, including regulating heartbeat, blood pressure, and energy metabolism. One of its key roles is muscle relaxation—it calms your nerves and helps relax your muscles, reducing issues like jaw clenching and cramps. Magnesium Citrate is the top-notch, highly absorbable form of magnesium, unlike the cheaper Magnesium Oxide, which can cause digestive upset.
Source: Saris NE et al. (2000). Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta, 294, 1-26.
Read more here.
- Jaw and Muscle Relief: Helps reduce jaw clenching, tooth grinding, and muscle cramps.
- Serotonin Booster: Essential for serotonin production.
- Immune Support: Strengthens your immune system.
- Hydration Helper: Supports healthy hydration.
What the Science Says:
Magnesium is crucial for over 300 biochemical reactions in your body, including regulating heartbeat, blood pressure, and energy metabolism. One of its key roles is muscle relaxation—it calms your nerves and helps relax your muscles, reducing issues like jaw clenching and cramps. Magnesium Citrate is the top-notch, highly absorbable form of magnesium, unlike the cheaper Magnesium Oxide, which can cause digestive upset.
Source: Saris NE et al. (2000). Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta, 294, 1-26.
Read more here.
Vitamin C (Ascorbic Acid) - 700 mg per Serving
Why You’ll Love It:
What the Science Says:
Vitamin C is not just an antioxidant; it’s an essential nutrient crucial for repairing tissues throughout your body. It plays a key role in immune function by boosting the production of white blood cells that fight infections. Vitamin C is highly effective at battling free radicals, reducing damage from toxins, and promoting speedy recovery!
Source: Padh H. (1991). Vitamin C: newer insights into its biochemical functions. Nutr Rev, 49(3), 65-70.
Read more here.
- Antioxidant Power: A potent antioxidant that neutralizes free radicals.
- Stress Defense: Helps your body fight off stress and supports quick recovery.
- Immune Booster: Strengthens your immune system.
- Vitamin E Recycler: Helps keep Vitamin E active.
What the Science Says:
Vitamin C is not just an antioxidant; it’s an essential nutrient crucial for repairing tissues throughout your body. It plays a key role in immune function by boosting the production of white blood cells that fight infections. Vitamin C is highly effective at battling free radicals, reducing damage from toxins, and promoting speedy recovery!
Source: Padh H. (1991). Vitamin C: newer insights into its biochemical functions. Nutr Rev, 49(3), 65-70.
Read more here.
RISE, RAVE, RECOVER, REPEAT
